The Nuclear Magnetic Resonance core carries out studies on a diverse array of biologically relevant systems in order to obtain detailed structural information. Analysis of such systems under physiological solution conditions can generate three-dimensional structure data and molecular flexibility/rigidity information and allows the detailed investigation of how biomolecules carry out their function. Ligand binding interactions with these biomacromolecules may also be amenable to study. Small molecule structural analyses are carried out as a complement to standard GC/LC – MS characterization studies.

The NMR Core can be used to assist in the work of research groups of the Wadsworth Center. These studies proceed as collaborative arrangements with staff members of the NMR group. With regard to initial questions concerning the feasibility of projects for NMR study, please contact Dr. David LeMaster, facility Director.

Equipment available:

• Bruker 600 MHZ Avance III spectrometer:
  • four radiofrequency channels for signal generation
  • ¹H,{²H,¹³C,¹⁵N} high sensitivity cryoprobe
• Bruker 500 MHz DRX spectrometer:
  • four radiofrequency channels for signal generation
  • ¹H,{²H,¹³C,¹⁵N} conventional probe