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Laura D. Kramer, Ph.D.

Laura D. Kramer, Ph.D.

Arbovirus Laboratory
Ph.D., Cornell Medical School
Postdoctoral training: University of California, Berkeley

Research Interests

The research program of the Arbovirus Laboratories focuses on basic and applied field and laboratory studies examining the interaction of mosquito and tick-borne arboviruses, arthropod vectors, and vertebrate hosts, and how this interaction impacts transmission intensity and perpetuation of the pathogen. The research program includes studies with alpha- and flavi- viruses, examining intrinsic (genetic) and extrinsic (temperature, dose, time after infection) factors affecting vectorial capacity. Our studies are currently focusing on the flavivirus, West Nile virus (WNV), which, like all flaviviruses, is a positive sense, single-stranded RNA virus. Research addresses the molecular epidemiology of this virus over time and space, as well as that of eastern equine (EEEV; alphavirus). WNV is being studied intensively to elucidate the virus-vector interactions and viral molecular biology that led to rapid evolution in North America. Research is underway to elucidate mechanisms by which arboviruses overwinter in temperate environments, particularly EEEV in northeastern USA. Other studies are ongoing that examine factors that constrain or enhance viral evolution and adaptation to arthropod and avian hosts. In particular, the lab is focusing on the role of intrahost viral diversity and how this impacts viral fitness.

Select Publications

Marcinkiewicz AL, Dupuis AP 2nd, Zamba-Campero M, Nowak N, Kraiczy P, Ram S, Kramer LD, Lin YP.
Blood treatment of Lyme borreliae demonstrates the mechanism of CspZ-mediated complement evasion to promote systemic infection in vertebrate hosts.
Cellular Microbiology.
Ciota AT, Bialosuknia SM, Zink SD, Brecher M, Ehrbar DJ, Morrissette MN, Kramer LD.
Effects of Zika Virus Strain and Aedes Mosquito Species on Vector Competence.
Emerging Infectious Diseases.
Ciota AT, Ehrbar DJ, Matacchiero AC, Van Slyke GA, Kramer LD.
The evolution of virulence of West Nile virus in a mosquito vector: implications for arbovirus adaptation and evolution - art. no. 71.
BMC Evolutionary Biology.
Ciota AT, Ehrbar DJ, Van Slyke GA, Willsey GG, Kramer LD.
Cooperative interactions in the West Nile virus mutant swarm.
BMC Evolutionary Biology.
Ciota AT, Ehrbar DJ, Van Slyke GA, Payne AF, Willsey GG, Viscio RE, Kramer LD.
Quantification of intrahost bottlenecks of West Nile virus in Culex pipiens mosquitoes using an artificial mutant swarm.
Infection, Genetics & Evolution.
Wang H, Nattanmai S, Kramer LD, Bernard KA, Tavakoli NP.
A duplex real-time RT-PCR assay for the detection of California serogroup and Cache Valley viruses.
Diagnostic Microbiology and Infectious Disease.
Chotkowski HL, Ciota AT, Jia Y, Puig-Basagoiti F, Kramer LD, Shi P-Y, Glaser RL.
West Nile virus infection of Drosophila melanogaster induces a protective RNAi response.
Hull R, Nattanmai S, Kramer LD, Bernard KA, Tavakoli NP.
A duplex real-time RT-PCR assay for the detection of St. Louis encephalitis and Eastern equine encephalitis viruses.
Diagnostic Microbiology and Infectious Disease.