Researchers in Molecular Genetics, using model systems including coronavirus, yeast, and mice, employ both focused and genome-wide approaches to investigate gene function and mechanism. Areas of investigation include virus replication and assembly; mobile DNA elements; and transcriptional regulation and chromatin structure.
Associated Researchers
Joan Curcio, Ph.D.
Host-Retrotransposon Interactions
Todd Gray, Ph.D.
Molecular Genetics of Mycobacteria
We use innovative molecular genomic approaches to address fundamental questions of mycobacterial biology. Our findings shed new light on the evolution and function of mycobacterial genomes, accelerating tuberculosis research.
Bruce J. Herron, Ph.D.
Mammalian Genomics
Paul Masters, Ph.D.
Molecular Genetics of Coronaviruses
Anil K. Ojha, Ph.D.
Mycobacterial Persistence and Pathogenesis
Jon Paczkowski, Ph.D.
Microbial Signal Transduction and Cell-cell Communication
Janice D. Pata, Ph.D.
Polymerases, Mutations, and the Evolution of Antimicrobial Drug Resistance
We study the molecular mechanisms by which multiple DNA polymerases replicate bacterial genomes completely, with high accuracy and tolerance for DNA damage, yet also create mutations that give rise to antibiotic resistance.