During infection, M. abscessus (yellow, enlarged for illustration) survives host macrophage cell capture by activation of SigM. We show that SigM induces 15 gene clusters, including a secretion system and the proteins it secretes. A 4-gene SigM-induced cluster produces a secreted toxin similar to one from M. tuberculosis that kills macrophages it infects (color coded subunits labeled). We anticipate that this toxin complex, together with the remaining uncharacterized complexes, promote M. abscessus survival and infection.