Bryan C. Duffy, Ph.D.

Bryan C. Duffy, PhD

Supervisor, Emerging Contaminants in Drinking Water Program / Liquid Chromatography
Technical Expert in Cannabis Reference Laboratory Program
Division of Environmental Health Sciences
Assistant Professor, Department of Environmental Health Sciences, University at Albany
PhD, University of Illinois at Urbana-Champaign (1999)

Research Interests

Clean drinking water is a priority for all New Yorkers. The emerging contaminant laboratory focuses on testing for recently regulated organic contaminants in drinking water, and the development of more sensitive and robust laboratory testing methods to quantitate them. The laboratory uses automated solid-phase extraction, along with liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography-mass spectrometry (GC-MS) instrumentation to quantitate contaminants at ultra-trace levels. Current routine testing of drinking water includes per- and polyfluoroalkyl substances (PFAS) by EPA Methods 533 and 537.1, as well as testing for the carcinogenic solvent 1,4-dioxane by EPA Method 522.

Dr. Duffy’s current research projects include developing methods for identifying methyl siloxane solvent contamination of water sources and covalent PFAS binding in biological lipids. Example contaminants that have been studied previously in the laboratory include PFAS in landfill leachate samples, tire rubber compounds in local stormwater run-off, and steroid hormones in drinking water.

Dr. Duffy is also the technical expert for the Wadsworth Cannabis Reference Laboratory Program’s liquid chromatography methods development. These methods include cannabinoid testing, mycotoxin testing, and pesticide testing. The Wadsworth Cannabis Reference Laboratory Program acts as New York State’s reference laboratory supporting safety and adverse reaction investigations by the Office of Cannabis Management.
 

Select Publications
Li L, Chmura SE, Judd CD, Duffy BC. New York perspectives of medical cannabis laboratory analysis. Medicinal Usage of Cannabis and Cannabinoids. 2023; Academic Press 77-89.
Duffy BC, Li L, Lu S, Dittmar MA, Delaney-Baldwin E, Durocher LA, Spink DC. Chemotyping of ∆8-THC-Containing e-Liquids Analyzed during the 2019-2020 New York State EVALI Investigation. J Anal Toxicol. 2022; Aug 13;46 (7): 743-749. DOI: 10.1093/jat/bkab107
Lu SJ, Li L, Duffy BC, Dittmar MA, Durocher LA, Panawennage D, Delaney-Baldwin ER, Spink DC. Investigation of Vaping Fluids Recovered From New York State E-Cigarette or Vaping Product Use-Associated Lung Injury Patients. Front Chem. 2021; Oct 27;9 748935. DOI: 10.3389/fchem.2021.748935
Duffy B, Li L, Lu S, Durocher L, Dittmar M, Delaney-Baldwin E, Panawennage D, LeMaster D, Navarette K, Spink D. Analysis of Cannabinoid-Containing Fluids in Illicit Vaping Cartridges Recovered from Pulmonary Injury Patients: Identification of Vitamin E Acetate as a Major Diluent. Toxics. 2020; 8 (1): 8. DOI: 10.3390/toxics8010008
Li L, Duffy BC, Durocher LA, Dittmar MA, Acosta RA, Delaney ER, Li L, Aldous KM, Spink DC. Potency Analysis of Medical Marijuana Products from New York State. Cannabis Cannabinoid Res. 2019; 4 (3): 195-203. DOI: 10.1089/can.2018.0037
Frohlich KM, Weintraub SF, Bell JT, Todd GC, Väre VYP, Schneider R, Kloos ZA, Tabe ES, Cantara WA, Stark CJ, Onwuanaibe UJ, Duffy BC, Basanta-Sanchez M, Kitchen DB, McDonough KA, Agris PF. Discovery of Small-Molecule Antibiotics against a Unique tRNA-Mediated Regulation of Transcription in Gram-Positive Bacteria. ChemMedChem. 2019; 14 (7): 758-769. DOI: 10.1002/cmdc.201800744
Kharenko OA, Patel RG, Brown SD, Calosing C, White A, Lakshminarasimhan D, Suto RK, Duffy BC, Kitchen DB, McLure KG, Hansen HC, van der Horst EH, Young PR. Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine. J Med Chem. 2018; 61 (18): 8202-8211. DOI: 10.1021/acs.jmedchem.8b00666
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