![Kerri Kluetzman Kerri Kluetzman](/sites/default/files/styles/wide/public/kluetzman_kerri.jpg?itok=BwL1dr5M)
![8-cell (embryonic day 2.5) mouse embryos 8-cell (embryonic day 2.5) mouse embryos](/sites/default/files/styles/thumbnail_medium_sm/public/embryos.png?itok=ogZUONPG)
![Chimeric knockout founder mouse Chimeric knockout founder mouse](/sites/default/files/styles/thumbnail_medium_sm/public/mouse.png?itok=GxgGm3Nb)
![Pronuclear microinjection of fertilized mouse embryo Pronuclear microinjection of fertilized mouse embryo](/sites/default/files/styles/thumbnail_medium_sm/public/PN3.jpg?itok=j1MIshAJ)
![mouse oviduct harboring recently fertilized eggs mouse oviduct harboring recently fertilized eggs](/sites/default/files/styles/thumbnail_medium_sm/public/oviduct-eggs2-crop.jpg?itok=iB0McVFh)
![mouse ICSI (Intra-cytoplasmic sperm injection) mouse ICSI (Intra-cytoplasmic sperm injection)](/sites/default/files/styles/thumbnail_medium_sm/public/ICSI-6.jpg?itok=ZqfPz_7N)
![mouse embryonic stem cells growing on a fibroblast layer mouse embryonic stem cells growing on a fibroblast layer](/sites/default/files/styles/thumbnail_medium_sm/public/ESC1.jpg?itok=T88AUrdx)
![fertilized mouse embryo fertilized mouse embryo](/sites/default/files/styles/thumbnail_medium_sm/public/0.5-dpc.jpg?itok=vpdCNMVO)
![Ubiquitous GFP expression in mouse blastocyst Ubiquitous GFP expression in mouse blastocyst](/sites/default/files/styles/thumbnail_medium_sm/public/GFP%20blast.jpeg?itok=usYLeAoc)
Kerri Kluetzman, Ph.D.
Research Interests
The primary objectives of this lab are to combine expertise in transgenic technologies with reproductive sciences in an effort to generate relevant mouse models and to study developmental and genetic origins of disease. Successful reproduction relies on high quality gametogenesis and complex networks of tightly regulated signaling cascades can have a profound impact on fertilization and fetal development. Genetic determinants contribute significantly, however, the environments in which these events occur both in vitro (e.g. in vitro fertilization) and in vivo (uterine environment) also play an important role in influencing fetal development and offspring phenotype. In addition to standard transgenic services, ongoing collaborations are designed to identify and define factors that contribute to successful fertilization and fetal developmental disorders.