Refeyn TwoMP Mass Photometer with MassFluidix HC add on

For measuring protein:protein and nucleic acid:protein interactions
Accurately measures the mass distribution of individual biomolecules in solution
Label free
Non-destructive
Minimal volume
Weak interactions can be measured using the MassFluidix HC add on unit that dilutes sample in ~37 mS
Exciting Instruments EI-FLEX

https://excitinginstruments.com
Single molecule fluorescence spectrometer for smFRET and fluorescence correlation spectroscopy for measuring
Protein and nucleic acid interactions
Dynamic protein conformational landscapes
Binding and diffusion rates, including protein:protein and protein:ligand binding
All performed in solution without surface immobilization
Cytiva Biacore T200

Surface plasmon resonance measures molecular interactions in real time with a wide range of applications
Binding kinetics ka and kd
Equilibrium Binding affinity KA
Concentration analysis
Cytiva Akta Pure M25

For preparative and analytical column chromatography
Flow rate 0.001-25 mL/min
Monitor up to 3 wavelengths (190-700 nm)
4 inlet valves
5 column positions with reverse flow to allow scouting or multiple column chromatography
Fraction collector 9-T allows for 0.02-50 mL Fractions
Sample pump
pH meter
Multiple columns for affinity, ion exchange, hydrophobic interaction and size exclusion chromatography
Many accessories
Molecular Devices Spectramax M2 Plate reader

Thermo Scientific Nanodrop Lite Plus

Measures purified protein, DNA, and RNA
Fast accurate measurements using 1-2 µL of sample
Beckman DU640 UV/VIS Spectroscopy

Equipped with software packages for measuring proteins, nucleic acids and performing kinetics
Peltier temperature control
Accessories include microcells for small volumes
Bio-Rad 2-D gel electrophoresis equipment
Protean IEF cell for 7, 11,17,18 and 24 cm immobilized pH gradient strips

Mini-PROTEAN and Mini Trans-Blot cells

Criterion and Criterion Blotter cells

PROTEAN II and PROTEAN II XL cells

Chemidoc XRS+ for gel imaging and densitometry of color, fluorescence, and chemiluminescence
