Ojha Laboratory

Li Y, Sharma MR, Koripella RK, Banavali NK, Agrawal RK, Ojha AK. Ribosome hibernation: a new molecular framework for targeting nonreplicating persisters of mycobacteria. Microbiology. 2021; 167 (2): 001035. DOI: 10.1099/mic.0.001035
Li Y, Corro JH, Palmer CD, Ojha AK. Progression from remodeling to hibernation of ribosomes in zinc-starved mycobacteria. Proc Natl Acad Sci U S A. 2020; DOI: 10.1073/pnas.2013409117
Richards JP, Cai W, Zill NA, Zhang W, Ojha AK. Adaptation of Mycobacterium tuberculosis to Biofilm Growth Is Genetically Linked to Drug Tolerance. Antimicrob Agents Chemother. 2019; 63 (11): e01213-19.
Li Y, Sharma MR, Koripella RK, Yang Y, Kaushal PS, Lin Q, Wade JT, Gray TA, Derbyshire KM, Agrawal RK, Ojha AK. Zinc depletion induces ribosome hibernation in mycobacteria. Proc. Natl. Acad. Sci. USA. 2018; Jul 23 (pii: 201804555):
Yang Y, Thomas J, Li Y, Vilch├Ęze C, Derbyshire KM, Jacobs WR Jr, Ojha AK. Defining a temporal order of genetic requirements for development of mycobacterial biofilms. Mol Microbiol. 2017; 105 (5): 794-809.
Yang Y, Kulka K, Montelaro RC, Reinhart TA, Sissons J, Aderem A, Ojha AK. A hydrolase of trehalose dimycolate induces nutrient influx and stress sensitivity to balance intracellular growth of Mycobacterium tuberculosis. Cell Host Microbe. 2014; 15 (2): 153-163.
Yang Y, Bhatti A, Ke D, Gonzalez-Juarrero M, Lenaerts A, Kremer L, Guerardel Y, Zhang P, Ojha AK. Exposure to a cutinase-like serine esterase triggers rapid lysis of multiple mycobacterial species. J Biol Chem. 2013; 288 (1): 382-392.