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Mycology - Research & Development

Recent publications are listed below. A more complete listing of publications is provided.

Applied Clinical Research

The laboratory conducts applied research to continually develop new platforms for fungal diagnostics, antifungal susceptibility/resistance patterns, and fungal typing.

Special Projects

  • Evaluation of MALDI-TOF-MS technology for yeast and mold identification
  • Development of real-time PCR assays for pathogenic molds and yeasts
  • Evaluation of molecular assays for fungal typing  
  • Fungal characterization from culture collection repository
  • Evaluation of commercially available tests/kits and in-house developed tests for antifungal susceptibility testing
  • Whole genome and transcriptome analyses of pathogenic fungi
  • Marathe A, Zhu Y, Chaturvedi V, Chaturvedi S. Utility of CHROMagar™ Candida Plus for presumptive identification of Candida auris from surveillance samples. Mycopathologia. 2022;187(5-6):527-534. DOI: 10.1007/s11046-022-00656-3
  • Pubmed Web Address

  • Jacobs SE, Jacobs JL, Dennis EK, Taimur S, Rana M, Patel D, Gitman M, Patel G, Schaefer S, Iyer K, Moon J, Adams V, Lerner P, Walsh TJ, Zhu Y, Anower MR, Vaidya MM, Chaturvedi S, Chaturvedi V. Candida auris Pan-Drug-Resistant to Four Classes of Antifungal Agents. Antimicrob Agents Chemother. 2022;66(7):e0005322. DOI: 10.1128/aac.00053-22
  • Pubmed Web Address

  • Kilburn S, Innes G, Quinn M, Southwick K, Ostrowsky B, Greenko JA, Lutterloh E, Greeley R, Magleby R, Chaturvedi V, Chaturvedi S. Antifungal Resistance Trends of Candida auris Clinical Isolates in New York and New Jersey from 2016 to 2020. Antimicrob Agents Chemother. 2022;66(3):e0224221. DOI: 10.1128/aac.02242-21
  • Pubmed Web Address

  • Freitas BL, Leach L, Chaturvedi V, Chaturvedi S. Reverse Transcription-Quantitative Real-Time PCR (RT-qPCR) Assay for the Rapid Enumeration of Live Candida auris Cells from the Health Care Environment.. J Clin Microbiol. 2022;60(2):e0077921. DOI: 10.1128/JCM.00779-21
  • Pubmed Web Address

  • Mirchin R, Czeresnia JM, Orner EP, Chaturvedi S, Murphy K, Nosanchuk JD. The Continuing Emergence of Candida blankii as a Pathogenic Fungus: A New Case of Fungemia in a Patient Infected with SARS-CoV-2. J Fungi (Basel). 2022;8(2): DOI: 10.3390/jof8020166
  • Pubmed Web Address

  • Karmarkar EN, O'Donnell K, Prestel C, Forsberg K, Gade L, Jain S, Schan D, Chow N, McDermott D, Rossow J, Toda M, Ruiz R, Hun S, Dale JL, Gross A, Maruca T, Glowicz J, Brooks R, Bagheri H, Nelson T, Gualandi N, Khwaja Z, Horwich-Scholefield S, Jacobs J, Cheung M, Walters M, Jacobs-Slifka K, Stone ND, Mikhail L, Chaturvedi S, Klein L, Vagnone PS, Schneider E, Berkow EL, Jackson BR, Vallabhaneni S, Zahn M, Epson E. Rapid Assessment and Containment of Candida auris Transmission in Postacute Care Settings-Orange County, California, 2019. Ann Intern Med. 2021;174(11):1554-1562. DOI: 10.7326/M21-2013
  • Pubmed Web Address

Basic Research

The laboratory’s externally funded basic research is focused on understanding pathogenic mechanisms of Cryptococcus gattii and Pseudogymnoascus destructans, the etiologic agents of cryptococcosis in humans and animals, and white nose syndrome (WNS) in bats, respectively.

Special Projects: 

  • Cryptococcus gattii pathogenic mechanisms. What pathogen and host factors dictate dissemination of C. gattii to the brain and gut?
  • Pseudogymnoascus destructans epidemiology, pathogenesis and outbreak investigations.
  • Tool generation for psychrophilic fungi to understand how fungi thrive in cold conditions and what unique traits make them pathogenic.

Grant: National Science Foundation (NSF) – 05/15/2012 to 04/30/2016
Title: Transformation System for Psychrophilic Fungi

  • Tharappel AM, Li Z, Zhu YC, Wu X, Chaturvedi S, Zhang QY, Li H. Calcimycin Inhibits Cryptococcus neoformans In Vitro and In Vivo by Targeting the Prp8 Intein Splicing. ACS Infect Dis. 2022;8(9):1851-1868. DOI: 10.1021/acsinfecdis.2c00137
  • Pubmed Web Address

  • Li Z, Tharappel AM, Xu J, Lang Y, Green CM, Zhang J, Lin Q, Chaturvedi S, Zhou J, Belfort M, Li H. Small-molecule inhibitors for the Prp8 intein as antifungal agents. Proc Natl Acad Sci U S A. 2021;118(2):e200881511. DOI: 10.1073/pnas.2008815118
  • Pubmed Web Address