Northwell Health Cancer Institute at Rego Park a Program of LIJ

We study mechanisms of protein biosynthesis in bacterial and eukaryotic cells, with a goal to understand bacterial drug resistance and identify new drug targets, using biochemical and high-resolution 3D cryo-EM techniques.

We use NextGen sequencing to determine frequencies and sequence dependence of polymerase errors, and computational methods for drug design, structure prediction, and elucidating chemical and conformational mechanisms.

We examine the genetics of brain abnormalities and behavioral impairments associated with neurodevelopmental disorders. Our current focus is identifying genes involved in abnormal forebrain connectivity and autism-relevant behaviors in mice.

We develop new technologies for fungal diagnostics and pathogenic mechanisms of Cryptococcus gattii and Pseudogymnoascus destructans, the etiologic agents of human cryptococcal meningitis and bat white nose syndrome, respectively.

Newborn Screening Program: We develop data visualizations and reports for public health surveillance. We provide education and work collaboratively with external stakeholders to improve the overall quality of the newborn screening system in NYS.

We study arbovirus adaptation and vector-virus interactions, focusing on West Nile virus and Culex mosquitoes. Areas of interest include mutant swarm dynamics, mechanisms of adaptation, microbial interactions and vectorial capacity.

We investigate ecological and genetic adaptation of Anopheles malaria vectors to environmental factors that impact vectorial capacity, population genetics/genomics, ecology and behavior, and novel ways to monitor and control vectors.

We focus on identifying conserved eukaryotic genes that control the activity of mobile retrotransposons and retroviruses for application as drug targets in the treatment of cancer, degenerative disease and AIDS.

We study mycobacteria and use molecular genetic approaches to investigate: global gene expression, at both transcriptional and translational levels; the mechanism of distributive conjugal transfer; and synthetic genetic interactions.

We are engaged in algorithms and software tool development for the prediction of RNA secondary structure and their applications to understand mechanisms of regulatory non-coding RNAs, with a recent focus on microRNAs and small bacterial RNAs.

We focus on the development and validation of assays to detect pathogens and toxins associated with bioterrorism or food-borne disease. We utilize methods such as real-time PCR, whole genome sequencing, and mass spectrometry for rapid detection of agents.

The Division of Laboratory Operations oversees the Wadsworth Center's operations at five facilities in the Albany area, totaling ~900,000 square feet of space and over 210 acres of real estate.

We use innovative molecular genomic approaches to address fundamental questions of mycobacterial biology. Our findings shed new light on the evolution and function of mycobacterial genomes, accelerating tuberculosis research.

We utilize an array of mammalian genomic tools to discover genetic modifiers that influence multifactorial diseases. These susceptibility loci are targets for diagnosis and treatment of similar disorders in humans.

We screen infants born in New York State for more than 50 conditions at birth and study the genetics of diseases affecting infants and children. 

We study the immunological aspect of the system biology effects from genetic susceptibilities and environmental stress defined as the exposome on autoimmune diseases, immune deficiencies, and neurodegenerative and neurobehavioral illnesses.

The goal of our research is to characterize the differences between antigenically naive (virgin) and memory T helper cells at the developmental, phenotypic and functional levels.