Ghosh Laboratory

Hurst-Hess K, Walz A, Yang Y, McGuirk H, Gonzalez-Juarrero M, Hatfull GF, Ghosh P, Ojha AK. Intrapulmonary Treatment with Mycobacteriophage LysB Rapidly Reduces Mycobacterium abscessus Burden. Antimicrob Agents Chemother. 2023; May (8:e0016223): DOI: 10.1128/aac.00162-23
Hurst-Hess K, McManaman C, Yang Y, Gupta S, Ghosh P. Hierarchy and networks in the transcriptional response of Mycobacterium abscessus to antibiotics. bioRxiv. 2023; Mar 17 (03.16.533064): DOI: 10.1101/2023.03.16.533064
Hurst-Hess KR, Phelps GA, Wilt LA, Lee RE, Ghosh P. Mab2780c, a TetV-like efflux pump, confers high-level spectinomycin resistance in mycobacterium abscessus. Tuberculosis (Edinb). 2023; Jan (138): 102295. DOI: 10.1016/
Hurst-Hess KR, Saxena A, Rudra P, Yang Y, Ghosh P. Mycobacterium abscessus HelR interacts with RNA polymerase to confer intrinsic rifamycin resistance. Mol Cell. 2022; 82 (17): 3166-77.e5. DOI: 10.1016/j.molcel.2022.06.034
Hurst-Hess KR, Rudra P, Ghosh P. Ribosome Protection as a Mechanism of Lincosamide Resistance in Mycobacterium abscessus. Antimicrob Agents Chemother. 2021; 65 (11): e0118421. DOI: 10.1128/AAC.01184-21
Rudra P, Hurst-Hess KR, Cotten KL, Partida-Miranda A, Ghosh P. Mycobacterial HflX is a ribosome splitting factor that mediates antibiotic resistance. Proc Natl Acad Sci U S A. 2020; 117 (1): 629-634. DOI: 10.1073/pnas.1906748117
Hurst-Hess K, Biswas R, Yang Y, Rudra P, Lasek-Nesselquist E, Ghosh P. Mycobacterial SigA and SigB Cotranscribe Essential Housekeeping Genes during Exponential Growth. mBio. 2019; 10 (3): e00273-19. DOI: 10.1128/mBio.00273-19
Rudra P, Hurst-Hess K, Lappierre P, Ghosh P. High Levels of Intrinsic Tetracycline Resistance in Mycobacterium abscessus Are Conferred by a Tetracycline-Modifying Monooxygenase. Antimicrob Agents Chemother. 2018; 62 (6): e00119-18. DOI: 10.1128/AAC.00119-18
Hurst-Hess K, Rudra P, Ghosh P. Mycobacterium abscessus WhiB7 Regulates a Species-Specific Repertoire of Genes To Confer Extreme Antibiotic Resistance. Antimicrob Agents Chemother. 2017; 61 (11): e01347-17. DOI: 10.1128/AAC.01347-17