Research in the Ghosh laboratory focuses on the mechanisms of antibiotic resistance in M. abscessus, which is a rapidly emerging nontuberculous mycobacteria (NTM) in patients with Cystic Fibrosis and underlying lung damage.
Specific projects include:
- Systems level understanding of changes that accompany exposure of M. abscessus to antibiotics.
- Identification of effectors that confer unique profiles of drug resistance.
- Screening of small molecule libraries for inhibitors of identified targets.
- Study the role of biofilm formation on antibiotic resistance of M. abscessus.
We use a combination of bacterial genetics, biochemistry and high throughput genomic analysis to decipher mechanisms of drug resistance.