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Research & Development

Research Projects:

  • Develop RNA based detection assays, such as transcription-mediated amplification for increased sensitivity and multiplex detection of parasites in complex specimens
  • Use of MALDI –TOF and next generation sequencing for species identification in parasitology
  • Generate a high resolution cryo-electron microscopy map of cytoplasmic ribosomes purified from Trypanosoma brucei
  • Develop a nucleic acid amplification based assay to differentiate Entamoeba histolytica from Entamoeba dispar in stool samples and to detect Entamoeba histolytica in liver specimens
  • Helminth identification utilizing conventional PCR and sequencing to aid in identification of helminth specimens; cytochrome oxidase I gene (also used in the Barcode of Life Database) is the most commonly used gene target
  • Pyrosequence to detect genetic mutations that are causal for, or associated with, drug resistance in Plasmodium falciparum and to evaluate the resistance patterns associated with specific populations or geographic locations


  • Hashem Y, Georges AD, Fu J, Buss SN, Jossinet F, Jobe A, Zhang Q, Liao HY, Grassucci RA, Bajaj C, Westhof E, Madison-Antenucci S, Frank J. High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome. Nature. 2013;494(7437):385-389.
  • Pubmed Web Address

  • Teal AE, Habura A, Ennis J, Keithly JS, Madison-Antenucci S. A New Real-Time PCR Assay for Improved Detection of the Parasite Babesia microti. Journal of Clinical Microbiology. 2012;50(3):903-908.
  • Pubmed Web Address

  • Joseph JT, Purtill K, Wong SJ, Munoz J, Teal A, Madison-Antenucci S, Horowitz HW, Aguero-Rosenfeld ME, Moore JM, Abramowsky C, Wormser GP. Vertical transmission of Babesia microti, United States. Emerging Infectious Diseases. 2012;18(8):1318-1321.
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  • Pubmed Web Address

  • Ennis JG, Teal AE, Habura A, Madison-Antenucci S, Keithly JS, Arguin PM, Barnwell JW, Collins WE, Mali S, Slutsker L, Dasilva A, Hwang J. Simian Malaria in a U.S. Traveler -- New York. Morbidity and Mortality Weekly Report . 2008;58(9):229-232.
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  • Hans J, Hajduk SL, Madison-Antenucci S. RNA-editing-associated Protein 1 Null Mutant Reveals Link to Mitochondrial RNA Stability. RNA. 2007;13(6):881-889.
  • Pubmed Web Address

  • Cirino NM, Tavakoli NP, Madison-Antenucci S, Egan C. Multiplex rtPCR in Microbiology. Real Time PCR in Microbiology: From Diagnosis to Characterization. Caister Academic Press. 2007;
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