Disease
Upper respiratory tract disease with fever, nasal congestion, and sore throat with cough. Some serotypes can cause gastroenteritis with diarrhea, vomiting and fever, while others can cause conjunctivitis and keratoconjunctivitis.
Transmission
Via the fecal-oral route through droplets or contact with objects contaminated with virus
Vaccination
No widespread use; a vaccine against some types has been given to military personnel in other countries
Age Association
All ages, often young children
Geographic Distribution
World wide
Seasonal Distribution
Spring
Summer
Fall
Winter
Preferred Specimens
Nasopharyngeal swabs, stool, rectal swabs, urine, eye swabs, CSF
Culture
Conventional tube culture; neutralization for serotyping
Molecular
Real-time and conventional PCR; Genmark RVP (Subgroups B & C, and E)