Researchers in Molecular Genetics, using model systems including coronavirus, yeast, and mice, employ both focused and genome-wide approaches to investigate gene function and mechanism. Areas of investigation include virus replication and assembly; mobile DNA elements; and transcriptional regulation and chromatin structure.
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Molecular Genetics
Associated Researchers
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Keith M. Derbyshire, Ph.D.
- Associate Director for Research and Technology
We study mycobacteria and use molecular genetic approaches to investigate: global gene expression, at both transcriptional and translational levels; the mechanism of distributive conjugal transfer; and synthetic genetic interactions.
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Jon Paczkowski, Ph.D.
- Microbial Signal Transduction and Cell-cell Communication
We seek to understand bacterial communication by investigating how bacteria interpret autoinducers and elicit appropriate gene expression, and, more globally, to understand how all organisms decode environmental stimuli.
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Janice D. Pata, Ph.D.
- Polymerases, Mutations, and the Evolution of Antimicrobial Drug Resistance
We study the molecular mechanisms by which multiple DNA polymerases replicate bacterial genomes completely, with high accuracy and tolerance for DNA damage, yet also create mutations that give rise to antibiotic resistance.